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Enantioselective Haloetherifications Catalyzed by 1,1’-Bi-2-naphthol (BINOL) Phosphates: From Symmetrical Alkenediols to Simple Alkenols

  • May 19, 2014

Asymmetric haloetherifications can be conducted using 1,1′‐bi‐2‐naphthol (BINOL) phosphates as catalyst. In combination with simple N‐haloamides such as N‐iodopyrrolidinone or N‐bromosuccinimide, good enantioselectivities can be achieved. However, depending on the substrate, the choice of BINOL phosphate is important, and different catalysts show remarkably different selectivities.

 

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