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Publications

Prof. Steven Ballet

Hormones and Behavior Volume 121

Effects of neuromedin U-8 on stress responsiveness and hypothalamus-pituitary-adrenal axis activity in male C57BL/6J mice.

De Prins A.; Allaoui W.; Medrano M.; Van Eeckhaut A.; Ballet S.; Smolders I.; De Bundel D. Hormones and Behavior, 2020, 121, 104666.

molecules

A New Family of Diverse Skin Peptides from the Microhylid Frog Genus Phrynomantis

Raaymakers, C.; Stijlemans, B.; Martin, C.; Zaman, S.; Ballet, S.; Martel, A.; Pasmans, F.; Roelants, K. Molecules 2020, 25(4), 912

Hollanders - ACS Catal 2020 - Cover

Zn-Catalyzed Nicotinate-Directed Transamidations in Peptide Synthesis

Hollanders, K.; Renders, E.; Gadais, C.; Masullo, D.; Van Raemdonck, L.; Wybon, C. C. D.; Martin, C.; Herrebout, W. A.; Maes, B. U. W.; Ballet, S. ACS Catal., 2020 DOI: 10.1021/acscatal.9b05074

Sci Adv

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.

Claff, T.; Yu, J.; Blais, V.; Patel, N.; Martin, C.; Wu, L.; Han, G. W.; Holleran, B. J.; Van der Poorten, O.; White, K. L.; Hanson, M. A.; Sarret, P.; Gendron, L.; Cherezov, V.; Katritch, V.; Ballet, S.; Liu, Z.-J.; Müller, C. E.; Stevens, R. C., Sci. Adv 2019, 5, eaax9115.

ACS Chem. Neurosci.

Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia.

Eiselt, E.; Gonzalez, S.; Martin, C.; Chartier, M.; Betti, C.; Longpré, J.-M.; Cavelier, F.; Tourwé, D.; Gendron, L.; Ballet, S.; Sarret, P., ACS Chem. Neurosci. 2019, 10, 4535-4544.

Current Medicinal Chemistry

Neuromedin U and Structural Analogs: an Overview of Their Structure, Function and Selectivity

De Prins A.; Van Eeckhaut A.; Smolders I.; Tourwé D.; Ballet S. Curr. Med. Chem. 2019, 26, 1.

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The 1,3-diyne linker as a rigid "i,i+7" staple for alpha-helix stabilization: Stereochemistry at work.

Verlinden, S.; Geudens, N.; Van holsbeeck, K.; Mannes, M.; Martins, J. C.; Verniest, G.; Ballet, S., J. Pept. Sci. 2019, 25, e3194

JOC

Solid-Phase Azopeptide Diels-Alder Chemistry for Aza-pipecolyl Residue Synthesis To Study Peptide Conformation.

Chingle, R.; Mulumba, M.; Chung, N. N.; Nguyen, T. M. D.; Ong, H.; Ballet, S.; Schiller, P. W.; Lubell, W. D., J. Org. Chem. 2019, 84, 6006-6016.

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Trifluoromethylated Proline Surrogates as Part of “Pro–Pro” Turn-Inducing Templates.

Gadais, C.; Van holsbeeck, K.; Moors, S. L. C.; Buyst, D.; Fehér, K.; Van Hecke, K.; Tourwé, D.; Brigaud, T.; Martin, C.; De Proft, F.; Pytkowicz, J.; Martins, J. C.; Chaume, G.; Ballet, S., ChemBioChem 2019, 20, 2513-2518.

Hepatology

Connexin and pannexin (hemi)channels: emerging targets in the treatment of liver disease.

Cooreman, A.; van Campenhout, R.; Ballet, S.; Annaert, P.; Van Den Bossche, B.; Colle, I.; Cogliati, B.; Vinken, M., Hepatology 2019, 69, 1317-1323

Bio Chem

Radiometal-labeled anti-VCAM-1 nanobodies as molecular tracers for atherosclerosis – impact of radiochemistry on pharmacokinetics.

Bala, G.; Crauwels, M.; Blykers, A.; Remory, I.; Marschall Andrea, L. J.; Dübel, S.; Dumas, L.; Broisat, A.; Martin, C.; Ballet, S.; Cosyns, B.; Caveliers, V.; Devoogdt, N.; Xavier, C.; Hernot, S., Biol. Chem., 2019; 400, 323.

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Primary Hepatocytes and Their Cultures for the Testing of Drug-Induced Liver Injury.

Vilas-Boas, V.; Cooreman, A.; Gijbels, E.; Van Campenhout, R.; Gustafson, E.; Ballet, S.; Annaert, P.; Cogliati, B.; Vinken, M., Advances in Pharmacology 2019, 85, 1-30.

Journal of peptide science

Trifluoromethylated proline surrogates as part of 'Pro-Pro' turn-inducing templates for the design of beta-hairpin mimetics.

Gadais, C.; Van Holsbeeck, K.; Moors, S.; Feher, K.; Pytkowicz, J.; Martins, J.; De Proft, F.; Tourwe, D.; Brigaud, T.; Martin, C.; Chaume, G.; Ballet, S., J. Pept. Sci. 2018, 24, S117-S117.

Journal of peptide science

A Bifunctional Biased Mu Opioid Agonist - Neuropeptide FF Receptor Antagonist as Analgesic with Improved Acute and Chronic Side Effects.

la Rochelle, A. D.; Guillemyn, K.; Dumitrascuta, M.; Gonzalez, S.; Martin, C.; Utard, V.; Quillet, R.; Schneider, S.; Daubeuf, F.; Willemse, T.; Mampuys, P.; Maes, B.; Frossard, N.; Bihel, F.; Spetea, M.; Simonin, F.; Ballet, S., J. Pept. Sci. 2018, 24, S156-S156.

Journal of peptide science

Injectable Peptide Hydrogels for Controlled Drug Release.

Mannes, M.; Martin, C.; Dumitrascuta, M.; Van Wanseele, Y.; Hernot, S.; Van Eeckhaut, A.; Madder, A.; Hoogenboom, R.; Spetea, M.; Ballet, S., J. Pept. Sci. 2018, 24, S159-S159.

Journal of peptide science

Design, synthesis and biological evaluation of stapled helical peptides targeting the myddosome.

Terriers, V.; Verhoeven, J.; Martin, C.; Hollanders, K.; Triballeau, N.; Mollat, P.; Van der Plas, S.; De Wilde, G.; Ballet, S., J. Pept. Sci. 2018, 24, S157-S157.

Journal of peptide science

Modulating peptide hydrogel strength through halogenation.

Vandeplassche, W.; Ballet, S.; Martin, C.; Hoogenboom, R.; Madder, A., J. Pept. Sci. 2018, 24, S109-S110.

Current Medicinal Chemistry

The Neurokinins: Peptidomimetic Ligand Design and Therapeutic Applications.

Gadais, C.; Ballet, S., Current Medicinal Chemistry 2018, 25, 1-44.

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Biodegradable Amphipathic Peptide Hydrogels as Extended-Release System for Opioid Peptides.

Martin, C.; Dumitrascuta, M.; Mannes, M.; Lantero, A.; Bucher, D.; Walker, K.; Van Wanseele, Y.; Oyen, E.; Hernot, S.; Van Eeckhaut, A.; Madder, A.; Hoogenboom, R.; Spetea, M.; Ballet, S., J. Med. Chem. 2018, 61, 9784-9789.

Antibody eng

Site-Specific Radioactive Labeling of Nanobodies.

Crauwels, M.; Massa, S.; Martin, C.; Betti, C.; Ballet, S.; Devoogdt, N.; Xavier, C.; Muyldermans, S. In Antibody Engineering: Methods and Protocols, Nevoltris, D.; Chames, P., Eds. Springer New York: New York, NY, 2018; pp 505-540.

Pain

A bifunctional-biased mu-opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects.

la Rochelle, A. D.; Guillemyn, K.; Dumitrascuta, M.; Martin, C.; Utard, V.; Quillet, R.; Schneider, S.; Daubeuf, F.; Willemse, T.; Mampuys, P.; Maes, B. U. W.; Frossard, N.; Bihel, F.; Spetea, M.; Simonin, F.; Ballet, S., Pain 2018, 159, 1705-1718.

biopolymer

Bromotryptophans and their incorporation in cyclic and bicyclic privileged peptides.

García-Pindado, J.; Willemse, T.; Goss, R.; Maes, B. U. W.; Giralt, E.; Ballet, S.; Teixidó, M., Biopolymers 2018, 109, e23112.

Willemse - Bioorg Med Chem Lett, 2018

Chemical space screening around Phe3 in opioid peptides : Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings.

Willemse, T.; Eiselt, E.; Hollanders, K.; Schepens, W.; van Vlijmen, H. W. T.; Chung, N. N.; Blais, V.; Holleran, B.; Longpré, J.-M.; Schiller, P. W.; Maes, B. U. W.; Sarret, P.; Gendron, L.; Ballet, S., Bioorg. Med. Chem. Lett. 2018, 28, 2320-2323

ACIE

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.

Pardon, E.; Betti, C.; Laeremans, T.; Chevillard, F.; Guillemyn, K.; Kolb, P.; Ballet, S.; Steyaert, J., Angew. Chem. Int. Ed. 2018, 57, 5292-5295.

A de prins

Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.

De Prins, A.; Martin, C.; Van Wanseele, Y.; Tomboly, C.; Tourwe, D.; Caveliers, V.; Holst, B.; Van Eeckhaut, A.; Rosenkilde, M. M.; Smolders, I.; Ballet, S., ACS Med. Chem. Lett 2018, 9, 496-501.

OVDP - ChemBioChem, 2018

Indoloazepinone-Constrained Oligomers as Cell-Penetrating and Blood-Brain-Barrier-Permeating Compounds.

Van der Poorten, O.; Legrand, B.; Vezenkov, L. L.; Garcia-Pindado, J.; Bettache, N.; Knuhtsen, A.; Pedersen, D. S.; Sanchez-Navarro, M.; Martinez, J.; Teixido, M.; Garcia, M.; Tourwe, D.; Amblard, M.; Ballet, S, ChemBioChem 2018, 19, 696-705.

J Med Chem cover

Binding-Site Compatible Fragment Growing Applied to the Design of β2-Adrenergic Receptor Ligands.

hevillard, F.; Rimmer, H.; Betti, C.; Pardon, E.; Ballet, S.; van Hilten, N.; Steyaert, J.; Diederich, W. E.; Kolb, P., J. Med. Chem. 2018, 61, 1118-1129.

Wybon - ACS Catalysis 2018 - TOC

Zn-Catalyzed tert-Butyl Nicotinate-Directed Amide Cleavage as a Biomimic of Metallo-Exopeptidase Activity.

Wybon, C. C. D.; Mensch, C.; Hollanders, K.; Gadais, C.; Herrebout, W. A.; Ballet, S.; Maes, B. U. W., ACS Catalysis 2018, 8, 203-218.

Med chem

Efficient One-Pot Access to Trisubstituted 2-Benzazepin-3-ones as Constrained Pseudopeptide Analogues and Privileged Scaffolds.

Van der Poorten, O.; Jida, M.; Tourwé, D.; Ballet, S., Medicinal Chemistry 2018, 14, 400-408.

OBC

Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR - Ullmann cross-coupling sequence.

Van der Poorten, O.; Van Den Hauwe, R.; Hollanders, K.; Maes, B. U. W.; Tourwe, D.; Jida, M.; Ballet, S., Org. Biomol. Chem. 2018, 16, 1242-1246.

Eur. J. Med. Chem

Development of potent and proteolytically stable human neuromedin U receptor agonists.

De Prins, A.; Martin, C.; Van Wanseele, Y.; Skov, L. J.; Tomboly, C.; Tourwe, D.; Caveliers, V.; Van Eeckhaut, A.; Holst, B.; Rosenkilde, M. M.; Smolders, I.; Ballet, S., Eur. J. Med. Chem. 2018, 144, 887-897.

Nature communications

Antimicrobial peptides in frog poisons constitute a molecular toxin delivery system against predators.

Raaymakers, C.; Verbrugghe, E.; Hernot, S.; Hellebuyck, T.; Betti, C.; Peleman, C.; Claeys, M.; Bert, W.; Caveliers, V.; Ballet, S.; Martel, A.; Pasmans, F.; Roelants, K., Nature Communications 2017, 8, 1495

ACS Med Chem Lett

χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.

Van der Poorten, O.; Van Den Hauwe, R.; Eiselt, E.; Betti, C.; Guillemyn, K.; Chung, N. N.; Hallé, F.; Bihel, F.; Schiller, P. W.; Tourwé, D.; Sarret, P.; Gendron, L.; Ballet, S., ACS Medicinal Chemistry Letters 2017, 8, 1177-1182.

EurJOC

Cyclisation To Form Small, Medium and Large Rings by Use of Catalysed and Uncatalysed Azide–Alkyne Cycloadditions (AACs).

This microreview briefly summarises recent developments in the cyclisation to form small, medium and large rings (five to 30 or more members) by way of both...

ACS Chem. Neurosci.

Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.

Starnowska, J.; Costante, R.; Guillemyn, K.; Popiolek-Barczyk, K.; Chung, N. N.; Lemieux, C.; Keresztes, A.; Van Duppen, J.; Mollica, A.; Streicher, J.; Vanden Broeck, J.; Schiller, P. W.; Tourwé, D.; Mika, J.; Ballet, S.; Przewlocka, B., ACS Chemical Neuroscience 2017, 8, 2315-2324.

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Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased beta(2) Adrenergic Receptor Ligands.

Martin, C.; Moors, S. L. C.; Danielsen, M.; Betti, C.; Fabris, C.; Pedersen, D. S.; Pardon, E.; Peyressatre, M.; Feher, K.; Martins, J. C.; Mathiesen, J. M.; Morris, M. C.; Devoogdt, N.; Caveliers, V.; De Proft, F.; Steyaert, J.; Ballet, S., Eur. Chem. J. 2017, 23, 9632-9640.

Advanced synthesis and catalysis

Amine Activation: N-Arylamino Acid Amide Synthesis from Isothioureas and Amino Acids.

Yan‐Ping, Z.; Pieter, M.; Sergey, S.; Steven, B.; W., M. B. U., Adv. Synth. Catal. 2017, 359, 2481-2498.

Eur J Pharm

Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain related behaviour in a rat model of neuropathy.

Starnowska, J.; Guillemyn, K.; Makuch, W.; Mika, J.; Ballet, S.; Przewlocka, B., Eur. J Pharm. 2017, 104, 221-229.

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In Vivo Imaging of the Stability and Sustained Cargo Release of an Injectable Amphipathic Peptide-Based Hydrogel.

Oyen, E.; Martin, C.; Caveliers, V.; Madder, A.; Van Mele, B.; Hoogenboom, R.; Hemot, S.; Ballet, S., Biomacromolecules 2017, 18, 994-1001.

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The Suzuki–Miyaura Cross-Coupling as a Versatile Tool for Peptide Diversification and Cyclization.

Willemse, T.; Schepens, W.; Vlijmen, H.; Maes, B.; Ballet, S., Catalysts 2017, 7, 74.

Pain

Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain.

Lagard, C.; Chevillard, L.; Guillemyn, K.; Risède, P.; Laplanche, J.-L.; Spetea, M.; Ballet, S.; Mégarbane, B., PAIN 2017, 158, 505-515.

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Injectable peptide-based hydrogel formulations for the extended in vivo release of opioids.

Martin, C.; Oyen, E.; Van Wanseele, Y.; Ben Haddou, T.; Schmidhammer, H.; Andrade, J.; Waddington, L.; Van Eeckhaut, A.; Van Mele, B.; Gardiner, J.; Hoogenboom, R.; Madder, A.; Spetea, M.; Ballet, S., Materials Today Chemistry 2017, 3, 49-59.

ACS Med Chem Lett

Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds.

Dyniewicz, J.; Lipiński, P. F. J.; Kosson, P.; Leśniak, A.; Bochyńska-Czyż, M.; Muchowska, A.; Tourwé, D.; Ballet, S.; Misicka, A.; Lipkowski, A. W., ACS Medicinal Chemistry Letters 2017, 8, 73-77.

J Med Chem cover

Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design.

Van der Poorten, O.; Knuhtsen, A.; Sejer Pedersen, D.; Ballet, S.; Tourwé, D., J. Med. Chem. 2016, 59, 10865-10890.

EurJOC

Synthesis of Heterocycle-Bridged Peptidic Macrocycles through 1,3-Diyne Transformations.

Verlinden, S.; Ballet, S.; Verniest, G., Eur. J. Org. Chem. 2016, 2016, 5807-5812.

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Controlled-release of opioids for improved pain management.

Martin, C.; De Baerdemaeker, A.; Poelaert, J.; Madder, A.; Hoogenboom, R.; Ballet, S., Mater. Today 2016, 19, 491-502.

Contrast Media Mol Imaging

Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments : a versatile strategy for multiple molecular imaging modalities.

Massa, S.; Vikani, N.; Betti, C.; Ballet, S.; Vanderhaegen, S.; Steyaert, J.; Descamps, B.; Vanhove, C.; Bunschoten, A.; Leeuwen, F. W. B.; Hernot, S.; Caveliers, V.; Lahoutte, T.; Muyldermans, S.; Xavier, C.; Devoogdt, N., Contrast Media Mol Imaging 2016, 11, 328-339.

Chem.: Eur. J

Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases.

Knuhtsen, A.; Legrand, B.; Van der Poorten, O.; Amblard, M.; Martinez, J.; Ballet, S.; Kristensen, J. L.; Pedersen, D. S., Chem.: Eur. J 2016, 22, 14022-14028.

Journal of peptide science

Development of Potent Neuromedin U Receptor Agonists.

De Prins, A.; Martin, C.; Caveliers, V.; Van Eeckhaut, A.; Holst, B.; Smolders, I.; Ballet, S., J. Pept. Sci. 2016, 22, S160-S160.

Journal of peptide science

Towards β-arrestin biased β2AR ligands: Rational Design of Nanobody Loop Mimetics.

Martin, C.; Betti, C.; Fabris, C.; Mathiesen, J. M.; Pardon, E.; Peyressatre, M.; Moors, S.; De Proft, F.; Feher, K.; Martins, J.; Morris, M. C.; Devoogdt, N.; Caveliers, V.; Steyaert, J.; Ballet, S., J. Pept. Sci. 2016, 22, S134-S134.

Journal of peptide science

Injectable Peptide Hydrogels for Controlled Drug Release.

Oyen, E.; Martin, C.; Hernot, S.; Gardiner, J.; Van Mele, B.; Madder, A.; Hoogenboom, R.; Spetea, M.; Ballet, S., J. Pept. Sci. 2016, 22, S84-S84

Eur J Pharm

Biological evaluation and molecular docking studies of AA3052, a compound containing a μ-selective opioid peptide agonist DALDA and D-Phe-Phe-D-Phe-Leu-Leu-NH2, a substance P analogue

Kowalczyk, A.; Kleczkowska, P.; Rekawek, M.; Kulik, K.; Lesniak, A.; Erdei, A.; Borics, A.; Martin, C.; Pawlik, K.; Lipkowski, A. W.; Benyhe, S.; Makulska-Nowak, H.; Ballet, S.; Bujalska-Zadrozny, M., Eur. J. Pharm. Sci 2016, 93, 11-20.

J Med Chem cover

Bifunctional Peptide-Based Opioid Agonist Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.

Guillemyn, K.; Starnowska, J.; Lagard, C.; Dyniewicz, J.; Rojewska, E.; Mika, J.; Chung, N. N.; Utard, V.; Kosson, P.; Lipkowski, A. W.; Chevillard, L.; Arranz-Gibert, P.; Teixido, M.; Megarbane, B.; Tourwe, D.; Simonin, F.; Przewlocka, B.; Schiller, P. W.; Ballet, S., J. Med. Chem. 2016, 59, 3777-3792.

Tetrahedron Lett

Synthesis of 3-amino-3,4-dihydro-1H-quinolin-2-ones through regioselective palladium-catalyzed intramolecular cyclization.

Halle, F.; Van der Poorten, O.; Doebelin, C.; Niederst, M.; Schneider, S.; Schmitt, M.; Ballet, S.; Bihel, F., Tetrahedron Lett. 2016, 57, 1547-1550.

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Injectable peptide hydrogels for controlled-release of opioids.

Martin, C.; Oyen, E.; Mangelschots, J.; Bibian, M.; Ben Haddou, T.; Andrade, J.; Gardiner, J.; Van Mele, B.; Madder, A.; Hoogenboom, R.; Spetea, M.; Ballet, S., MedChemComm 2016, 7, 542-549.

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Mixed α/β-Peptides as a Class of Short Amphipathic Peptide Hydrogelators with Enhanced Proteolytic Stability.

Mangelschots, J.; Bibian, M.; Gardiner, J.; Waddington, L.; Van Wanseele, Y.; Van Eeckhaut, A.; Acevedo, M. M. D.; Van Mele, B.; Madder, A.; Hoogenboom, R.; Ballet, S., Biomacromolecules 2016, 17, 437-445.

OBC

Efficient one-pot synthesis of amino-benzotriazolodiazocinone scaffolds via catalyst-free tandem Ugi-Huisgen reactions.

Barlow, T. M. A.; Jida, M.; Guillemyn, A. K.; Tourwe, D.; Caveliers, V.; Ballet, S., Org. Biomol. Chem. 2016, 14, 4669-4677.

Neuropeptides

Synthesis and binding characteristics of [3H]neuromedin N, a NTS2 receptor ligand.

Toth, F.; Mallareddy, J. R.; Tourwe, D.; Lipkowski, A. W.; Bujalska-Zadrozny, M.; Benyhe, S.; Ballet, S.; Toth, G.; Kleczkowska, P., Neuropeptides 2016, 57, 15-20.

ACS Med Chem Lett

Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.

Betti, C.; Starnowska, J.; Mika, J.; Dyniewicz, J.; Frankiewicz, L.; Novoa, A.; Bochynska, M.; Keresztes, A.; Kosson, P.; Makuch, W.; Van Duppen, J.; Chung, N. N.; Broeck, J. V.; Lipkowski, A. W.; Schiller, P. W.; Janssens, F.; Ceusters, M.; Sommen, F.; Meert, T.; Przewlocka, B.; Tourwe, D.; Ballet, S., ACS Med. Chem. Lett. 2015, 6, 1209-1214.

Org Lett

T3P-promoted, mild one-pot syntheses of constrained polycyclic lactam dipeptide analogues via stereoselective Pictet-Spengler and Meyers’ lactamization reactions.

Jida, M.; Van der Poorten, O.; Guillemyn, K.; Urbanczyk-Lipkowska, Z.; Tourwe, D.; Ballet, S., Org. Lett. 2015, 17, 4482-4485.

OBC

Oxidative alpha,omega-diyne coupling as an approach towards novel peptidic macrocycles.

Verlinden, S.; Geudens, N.; Martins, J. C.; Tourwe, D.; Ballet, S.; Verniest, G., Org. Biomol. Chem. 2015, 13, 9398-9404.

Willemse chemcatchem

Suzuki-Miyaura Diversification of Amino Acids and Dipeptides in Aqueous Media.

Willemse, T.; Van Imp, K.; Goss, R. J. M.; Van Vlijmen, H. W. T.; Schepens, W.; Maes, B. U. W.; Ballet, S., ChemCatChem 2015, 7, 2055-2070.

Eur. J. Med. Chem

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist – Neurokinin-1 antagonist peptidomimetics.

Guillemyn, K.; Kleczkowska, P.; Lesniak, A.; Dyniewicz, J.; Van der Poorten, O.; Van den Eynde, I.; Keresztes, A.; Varga, E.; Lai, J.; Porreca, F.; Chung, N. N.; Lemieux, C.; Mika, J.; Rojewska, E.; Makuch, W.; Van Duppen, J.; Przewlocka, B.; Vanden Broeck, J.; Lipkowski, A. W.; Schiller, P. W.; Tourwe, D.; Ballet, S., Eur. J. Med. Chem 2015, 92, 64-77.

Nature Structural & Molecular Biology

Structural basis for bifunctional peptide recognition at human delta-opioid receptor.

Fenalti, G.; Zatsepin, N. A.; Betti, C.; Giguere, P.; Han, G. W.; Ishchenko, A.; Liu, W.; Guillemyn, K.; Zhang, H.; James, D.; Wang, D.; Weierstall, U.; Spence, J. C. H.; Boutet, S.; Messerschmidt, M.; Williams, G. J.; Gati, C.; Yefanov, O. M.; White, T. A.; Oberthuer, D.; Metz, M.; Yoon, C. H.; Barty, A.; Chapman, H. N.; Basu, S.; Coe, J.; Conrad, C. E.; Fromme, R.; Fromme, P.; Tourwé, D.; Schiller, P. W.; Roth, B. L.; Ballet, S.; Katritch, V.; Stevens, R. C.; Cherezov, V., Nat Struct Mol Biol 2015, 22, 265-268.

Bibian - JMCB

Rational design of a hexapeptide hydrogelator for controlled-release drug delivery.

Bibian, M.; Mangelschots, J.; Gardiner, J.; Waddington, L.; Diaz Acevedo, M. M.; De Geest, B. G.; Van Mele, B.; Madder, A.; Hoogenboom, R.; Ballet, S., J. Mater. Chem. B 2015, 3, 759-765.

Plos One

Draft genome sequence analysis of a Pseudomonas putida W15Oct28 strain with antagonistic activity to Gram-positive and Pseudomonas sp. pathogens.

Ye, L. M.; Hildebrand, F.; Dingemans, J.; Ballet, S.; Laus, G.; Matthijs, S.; Berendsen, R.; Cornelis, P., Plos One 2014, 9, e110038

Journal of peptide science

Rational Design of Injectable Hexapeptide Hydrogelators for Controlled-Release Drug Delivery.

Bibian, M.; Mangelschots, J.; Martin, C.; Gardiner, J.; Waddington, L.; Acevedo, M. M. D.; Van Mele, B.; Madder, A.; Hoogenboom, R.; Ballet, S., J. Pept. Sci​​​​​​​. 2014, 20, S208-S208

Org Lett

Synthesis of Fused 3-Aminoazepinones via Trapping of a new Class of Cyclic Seven-Membered Allenamides with Furan.

Schurgers, B.; Brigou, B.; Urbanczyk-Lipkowska, Z.; Tourwe, D.; Ballet, S.; De Proft, F.; Van Lommen, G.; Verniest, G., Org. Lett. 2014, 16, 3712-3715.

ACS comb Sci

One-Pot Isomerization-Cross Metathesis-Reduction (ICMR) Synthesis of Lipophilic Tetrapeptides

Jida, M.; Betti, C.; Schiller, P. W.; Tourwe, D.; Ballet, S., ACS Comb. Sci. 2014, 16, 342-351.

Nat. Prod. Commun

Structure revision of N-mercapto-4-formylcarbostyril produced by Pseudomonas fluorescens G308 to 2-(2-hydroxyphenyl)thiazole-4-carbaldehyde [aeruginaldehyde].

Ye, L. M.; Cornelis, P.; Guillemyn, K.; Ballet, S.; Christophersen, C.; Hammerich, O., Nat. Prod. Commun. 2014, 9, 789-794.

Org Lett

The First One-Pot Synthesis of l-7-Iodotryptophan from 7-Iodoindole and Serine, and an Improved Synthesis of Other l-7-Halotryptophans.

Smith, D. R. M.; Willemse, T.; Gkotsi, D. S.; Schepens, W.; Maes, B. U. W.; Ballet, S.; Goss, R. J. M., Org. Lett. 2014, 16, 2622-2625.

ACS Med Chem Lett

In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt1-DALDA Analogues.

Ballet, S.; Betti, C.; Novoa, A.; Tomboly, C.; Nielsen, C. U.; Helms, H. C.; Lesniak, A.; Kleczkowska, P.; Chung, N. N.; Lipkowski, A. W.; Brodin, B.; Tourwe, D.; Schiller, P. W., ACS Med. Chem. Lett. 2014, 5, 352-357.

Curr. Pharm. Des

Hybrid Opioid/Non-Opioid Ligands in Pain Research.

Kleczkowska, P.; W Lipkowski, A.; Tourwe, D.; Ballet, S., Curr. Pharm. Des 2013, 19, 7435-7450.

Org Lett

Highly Diastereoselective Synthesis of 1-Carbamoy1-4-aminoindoloazepinone Derivatives via the Ugi Reaction.

Jida, M.; Betti, C.; Urbanczyk-Lipkowska, Z.; Tourwe, D.; Ballet, S., Org. Lett. 2013, 15, 5866-5869.

Biometals

A combinatorial approach to the structure elucidation of a pyoverdine siderophore produced by a Pseudomonas putida isolate and the use of pyoverdine as a taxonomic marker for typing P. putida subspecies.

Ye, L. M.; Ballet, S.; Hildebrand, F.; Laus, G.; Guillemyn, K.; Raes, J.; Matthijs, S.; Martins, J.; Cornelis, P., Biometals 2013, 26, 561-575.

Journal of peptide science

Stabilisation of a short α-helical VIP fragment by side chain to side chain cyclisation: a comparison of common cyclisation motifs by circular dichroism.

Frankiewicz, L.; Betti, C.; Guillemyn, K.; Tourwé, D.; Jacquot, Y.; Ballet, S., J. Pept. Sci. 2013, 19, 423-432.

Physiol. Plant.

Regulatory mechanisms after short-term and long-term perturbed lysine biosynthesis in the aspartate pathway: the need for isogenes in Arabidopsis thaliana.

Van Bochaute, P.; Novoa, A.; Ballet, S.; Rognes, S. E.; Angenon, G. Physiol. Plant. 2013, 149, 449-460.

Pharmacological Reports

Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20.

Kleczkowska, P.; Bojnik, E.; Leśniak, A.; Kosson, P.; Van den Eynde, I.; Ballet, S.; Benyhe, S.; Tourwé, D.; Lipkowski, A. W., Pharmacological Reports 2013, 65, 836-846.

Org Lett

Amino Triazolo Diazepines (Ata) as Constrained Histidine Mimics.

Buysse, K.; Farard, J.; Nikolaou, A.; Vanderheyden, P.; Vauquelin, G.; Pedersen, D. S.; Tourwe, D.; Ballet, S., Org. Lett. 2011, 13, 6468-6471.

J Med Chem cover

Variation of the Net Charge, Lipophilicity, and Side Chain Flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.

Novoa, A.; Van Dorpe, S.; Wynendaele, E.; Spetea, M.; Bracke, N.; Stalmans, S.; Betti, C.; Chung, N. N.; Lemieux, C.; Zuegg, J.; Cooper, M. A.; Tourwé, D.; De Spiegeleer, B.; Schiller, P. W.; Ballet, S., J. Med. Chem. 2012, 55, 9549-9561.

Molec. Brain

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera.

Guillemyn, K.; Kleczkowska, P.; Novoa, A.; Vandormael, B.; Van den Eynde, I.; Kosson, P.; Asim, M. F.; Schiller, P. W.; Spetea, M.; Lipkowski, A. W.; Tourwé, D.; Ballet, S., Molecular Brain 2012, 5, 4-4.

chemmedchem

Asymmetric Synthesis and Conformational Analysis by NMR Spectroscopy and MD of Aba- and alpha-MeAba-Containing Dermorphin Analogues.

Vandormael, B.; De Wachter, R.; Martins, J. C.; Hendrickx, P. M. S.; Keresztes, A.; Ballet, S.; Mallareddy, J. R.; Toth, F.; Toth, G.; Tourwe, D., ChemMedChem 2011, 6, 2035-2047.

J Med Chem cover

Design of Novel Neurokinin 1 Receptor Antagonists Based on Conformationally Constrained Aromatic Amino Acids and Discovery of a Potent Chimeric Opioid Agonist-Neurokinin 1 Receptor Antagonist.

Ballet, S.; Feytens, D.; Buysse, K.; Chung, N. N.; Lemieux, C.; Tumati, S.; Keresztes, A.; Van Duppen, J.; Lai, J.; Varga, E., J. Med. Chem. 2011, 54, 2467-2476.

molecular pain

PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects.

Kleczkowska, P.; Kosson, P.; Ballet, S.; Van den Eynde, I.; Tsuda, Y.; Tourwé, D.; Lipkowski, A. W., Mol Pain 2010, 6, 86-92.

Bioorg. Med. Chem. Lett.

Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.

Ballet, S.; Marczak, E. D.; Feytens, D.; Salvadori, S.; Sasaki, Y.; Abell, A. D.; Lazarus, L. H.; Balboni, G.; Tourwé, D., Bioorg. Med. Chem. Lett. 2010, 20, 1610-1613.

hlca.v100.12.cover_.jpg

Synthesis and High-Resolution NMR Structure of a beta(3)-Octapeptide with and without a Tether Introduced by Olefin Metathesis.

Ebert, M. O.; Gardiner, J.; Ballet, S.; Abell, A. D.; Seebach, D., Helv. Chim. Acta 2009, 92, 2643-2658.

Bioorg. Med. Chem. Lett.

Conformationally constrained opioid ligands: The Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.

Ballet, S.; Feytens, D.; De Wachter, R.; De Vlaeminck, M.; Marczak, E. D.; Salvadori, S.; de Graaf, C.; Rognan, D.; Negri, L.; Lattanzi, R.; Lazarus, L. H.; Tourwe, D.; Balboni, G., Bioorg. Med. Chem. Lett. 2009, 19, 433-437.

Tetrahedron

Influence of ring substitution on the conformation and beta-turn mimicry of 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one peptide mimetics.

De Wachter, R.; Brans, L.; Ballet, S.; Van den Eynde, I.; Feytens, D.; Keresztes, A.; Toth, G.; Urbanczyk-Lipkowska, Z.; Tourwe, D., Tetrahedron 2009, 65, 2266-2278.

Tetrahedron

Cross-metathesis and ring-closing metathesis reactions of amino acid-based substrates.

Vernall, A. J.; Ballet, S.; Abell, A. D., Tetrahedron 2008, 64, 3980-3997.

J Med Chem cover

Blood-Brain barrier penetration by two dermorphin tetrapeptide analogues: Role of lipophilicity vs structural flexibility.

Ballet, S.; Misicka, A.; Kosson, P.; Lemieux, C.; Chung, N. N.; Schiller, P. W.; Lipkowski, A. W.; Tourwe, D., J. Med. Chem. 2008, 51, 2571-2574.

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Multiple Ligands in Opioid Research.

Ballet, S.; Pietsch, M.; Abell, A. D., Protein Pep. Lett. 2008, 15, 668-682.

J Med Chem cover

Endomorphin-2 with a beta turn backbone constraint retains the potent mu-opioid receptor agonist properties.

Tomboly, C.; Ballet, S.; Feytens, D.; Kover, K. E.; Borics, A.; Lovas, S.; Al-Khrasani, M.; Furst, Z.; Toth, G.; Benyhe, S.; Tourwe, D., J. Med. Chem. 2008, 51, 173-177.

J. Sep sci

High-performance liquid chromatographic separation of stereoisomers of N-phthaloyl-protected amino acids and dipeptidomimetics.

Illisz, I.; Ballet, S.; Van Rompaey, K.; De Wachter, R.; Tourwe, D.; Armstrong, D. W.; Peter, A., J. Sep. Sci. 2007, 30, 1881-1887.

Bioorg. Med. Chem. Lett.

Novel Selective human melanocortin-3 receptor ligands : Use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold.

Ballet, S.; Mayorov, A. V.; Cai, M. Y.; Tymecka, D.; Chandler, K. B.; Palmer, E. S.; Van Rompaey, K.; Misicka, A.; Tourwe, D.; Hruby, V. J., Bioorg. Med. Chem. Lett. 2007, 17, 2492-2498.

Tetrahedron

Derivatization of 1-phenyl substituted 4-amino-2benzazepin-3-ones : evaluation of Pd-catalyzed coupling reactions.

Ballet, S.; De Wachter, R.; Maes, B. U. W.; Tourwe, D., Tetrahedron 2007, 63, 3718-3727.

Journal of peptide science

Bradykinin analogs containing the 4-amino-2-benzazepin-3-one scaffold at the C-terminus.

Ballet, S.; De Wachter, R.; Van Rompaey, K.; Tömböly, C.; Feytens, D.; Töth, G.; Quartara, L.; Cucchi, P.; Meini, S.; Tourwé, D., J. Pept. Sci. 2007, 13, 164-170.

J Med Chem cover

beta-Methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists.

Toth, G.; Ioja, E.; Tomboly, C.; Ballet, S.; Tourwe, D.; Peter, A.; Martinek, T.; Chung, N. N.; Schiller, P. W.; Benyhe, S.; Borsodi, A., J. Med. Chem. 2007, 50, 328-333.

EurJOC

Synthesis and evaluation of the beta-turn properties of 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-ones and of their spirocyclic derivative.

Van Rompaey, K.; Ballet, S.; Tomboly, C.; De Wachter, R.; Vanommeslaeghe, K.; Biesemans, M.; Willem, R.; Tourwe, D., Eur. J. Org. Chem. 2006, 2899-2911.

J Med Chem cover

New 2',6'-dimethyl-L-Tyrosine (Dmt) Opioid Peptidomimetics Based on the Aba-Gly Scaffold. Development of Unique µ-Opioid Receptor Ligands.

Ballet, S.; Salvadori, S.; Trapella, C.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H.; Negri, L.; Giannini, E.; Lattanzi, R.; Tourwe, D.; Balboni, G., J. Med. Chem. 2006, 49, 3990-3993.

Synlett

Synthesis of substituted 4-amino-2-benzezepin-3-ones via N-acyliminium ion cycliations.

Ballet, S.; Urbanczyk-Lipkowska, Z.; Tourwe, D., Synlett 2005, 2791-2795.

Synthesis of 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones and study of their beta-turn inducing properties.

Van den Eynde, I.; Van Rompaey, K.; Ballet, S.; De Wachter, R.; Van Ommeslaeghe, K.; Biesemans, M.; Willem, R.; Tourwe, D., Biopolymers 2005, 80, 569-569.

Synthesis and biological evaluation of constrained analogues of the opioid peptide H-Tyr-D-Ala-Phe-Gly-NH2 using 4-amino-2-benzazepin-3-one scaffold.

Ballet, S.; Frycia, A.; Piron, J.; Chung, N.; Schiller, P. W.; Kosson, P.; Lipkowski, A.; Tourwe, D., J. Pept. Res. 2005, 66, 222-230.

Prof. Ulrich Hennecke

Journal of structural biology

Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqdC, a mycobacterial dioxygenase of the α/β-hydrolase fold family

S. C. Wullich, S. Kobus, M. Wienhold, U. Hennecke, S. H. J. Smits, S. Fetzner, J. Struc. Biol. 2019, 207, 287-294.

Environ. Microbiol.

Bromination of alkyl quinolones by Microbulbifer sp. HZ11, a marine Gammaproteobacterium, modulates their antibacterial activity

N. H. Ritzmann, A. Mährlein, S. Ernst, U. Hennecke, S. L. Drees, S. Fetzner, Environ. Microbiol. 2019, 21, 2595-2609.

ACIE

Organocatalytic, Enantioselective Dichlorination of Unfunctionalized Alkenes

V. Wedek, R. Van Lommel, C. G. Daniliuc, F. De Proft, U. Hennecke, Angew. Chem. Int. Ed. 2019, 58, 9239-9243.

Org Lett

Stable Bromiranium Ion Salts as Reagents for Biomimetic Indole Terpenoid Cyclizations

J. Bock, C. G. Daniliuc, U. Hennecke, Org. Lett. 2019, 21, 1704-1707.

OBC

Synthesis, structural characterisation, and synthetic application of stable seleniranium ions

J. Bock, C. G. Daniliuc, K. Bergander, C. Mück-Lichtenfeld, U. Hennecke, Org. Biomol. Chem. 2019, 17, 3181-3185.

Beilstein J. Org. Chem.

Synthesis and biological activity of methylated derivatives of the Pseudomonas metabolites HHQ, HQNO and PQS

S. Thierbach, M. Wienhold, S. Fetzner, U. Hennecke, Beilstein J. Org. Chem. 2019, 15, 187-193.

Journal-of-Biological-Chemistry.jpg

PqsL uses reduced flavin to produce 2-hydroxylaminobenzoylacetate, a preferred PqsBC substrate in alkyl quinolone biosynthesis in Pseudomonas aeruginosa

S. L. Drees, S. Ernst, B. Belviso, N. Jagmann, U. Hennecke, S. Fetzner, J. Biol. Chem. 2018, 293, 9345-9357.

EurJOC

An Enantioselective Iodolactonization/Cross-Coupling Protocol for the Synthesis of Highly-Substituted Enol Lactones

C. Fricke, M. Wilking, C. G. Daniliuc, U. Hennecke, Eur. J. Org. Chem. 2018, 3158-3166.

ACS Chem. Biol.

Chemical Modification and Detoxification of the Pseudomonas aeruginosa Toxin 2-Heptyl-4-hydroxyquinoline N-Oxide by Environmental and Pathogenic Bacteria

S. Thierbach, F. S. Birmes, M. C. Letzel, U. Hennecke, S. Fetzner, ACS Chem. Biol. 2017, 12, 2305-2312.

Chem.: Eur. J

Stable Bromiranium Ions with Weakly-Coordinating Counterions as Efficient Electrophilic Brominating Agents

C. Ascheberg, J. Bock, F. Buß, C. Mück-Lichtenfeld, C. G. Daniliuc, K. Bergander, F. Dielmann, U. Hennecke, Chem. Eur. J. 2017, 23, 11578-11586.

Chem.: Eur. J

Enantioselective Catalysis using short, structurally-defined DNA Hairpins as Scaffold for Hybrid Catalysts

J. J. Marek, R. Singh, A. Heuer, U. Hennecke, Chem. Eur. J. 2017, 23, 6004-6008.

Chem.: Eur. J

Monomeric cinchona alkaloid-based catalysts for highly enantioselective bromolactonisation of alkynes

M. Wilking, C. G. Daniliuc, U. Hennecke, Chem. Eur. J. 2016, 51, 18601-18607.

Journal-of-Biological-Chemistry.jpg

PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism

S. L. Drees, C. Li, F. Prasetya, M. Saleem, I. Dreveny, P. Williams, U. Hennecke, J. Emsley, S. Fetzner, J. Biol. Chem. 2016, 291, 6610-6624.

1-Iodo-n-Heteroatom-Functionalized Alkanes (n ≥ 2 with Both Functions Formed Simultaneously: Synthesis by Addition across C=C Bond

U. Hennecke in Science of Synthesis Knowledge Updates 2015/2, T. Wirth (Ed.), Thieme, Stuttgart, 2015, 449-465.

Org Lett

Homohalocyclization: Electrophilic Bromine-Induced Cyclizations of Cyclopropanes

C. Rösner, U. Hennecke, Org. Lett. 2015, 17, 3226-3229.

Iodoalkanes: Synthesis by Addition to π-Type C-C-Bonds (Update 2014)

U. Hennecke in Science of Synthesis Knowledge Updates 2015/2, T. Wirth (Ed.), Thieme, Stuttgart, 2015, 437-448.

Synlett

Asymmetric, Organocatalytic Bromolactonization of Allenoic Acids

M. Wilking, C. G. Daniliuc, U. Hennecke, Synlett 2014, 25, 1701-1704.

Synlett

Desymmetrization as a Strategy in Asymmetric Halocyclization Reactions

M. Wilking, U. Hennecke, Synlett 2014, 25, 1633-1637.

Addition Reactions with Formation of Carbon–Halogen Bonds

U. Hennecke, T. Wald, C. Rösner, T. Robert, M. Oestreich, in Comprehensive Organic Synthesis 2nd Edition, G. A. Molander, P. Knochel (Eds.), Elsevier, Oxford, 2014, Vol. 7 (Oxidation), 638-691.

JACS

Enantioselective, Desymmetrizing Bromolactonization of Alkynes

M. Wilking, C. Mück-Lichtenfeld, C. G. Daniliuc, U. Hennecke, J. Am. Chem. Soc. 2013, 135, 8133-8136.

Science

Revealing the Positive Side of Fluorine

U. Hennecke, Science 2013, 340, 41-42.

Org Lett

Efficient Synthesis of Chiral 2,2’-Bipyrrolidines by an anti-Selective Alkene Diamination

C H. Müller, R. Fröhlich, C. G. Daniliuc, U. Hennecke, Org. Lett. 2012, 14, 5944-5947.

Chembiochem

Hydrolase-Like Properties of a Cofactor-Independent Dioxygenase

S. Thierbach, K. Büldt-Karentzopoulos, A. Dreiling, U. Hennecke, S. König, S. Fetzner, ChemBioChem 2012, 13, 1125-1127.

Synlett

Catalytic, Asymmetric, Bromine-induced Semipinacol Rearrangements at Unactivated Double Bonds

C. H. Müller, M. Wilking, A. Rühlmann, B. Wibbeling, U. Hennecke, Synlett 2011, 2043-2047.

Org Lett

Enantioselective Haloetherification by Asymmetric Opening of meso-Halonium Ions

U. Hennecke, C. H. Müller, R. Fröhlich, Org. Lett. 2011, 13, 860-863.

Org Lett

Sequential Double α-Arylation of N-Allylureas by Asymmetric Deprotonation and N→C Aryl Migration

D. J. Tetlow, U. Hennecke, J. Raftery, M. J. Waring, D. S. Clarke, J. Clayden, Org. Lett. 2010, 12, 5442-5445.

Phys. Chem. Chem. Phys.

The Origin of the Conformational Preference of N,N'-diaryl-N,N'-dimethyl ureas

J. Clayden, U. Hennecke, M. A. Vincent, I. H. Hillier, M. Helliwell, Phys. Chem. Chem. Phys. 2010, 12, 15056-15064.

Chem.: Eur. J

Crystal Structure of the T(6-4)C Lesion in Complex with a (6-4) DNA Photolyase and Repair of UV-Induced (6-4) and Dewar Photolesions

A. F. Glas, S. Schneider, M. J. Maul, U. Hennecke, T. Carell, Chem. Eur. J. 2009, 15, 10387-10396.

JACS

N to C Aryl Migration in Lithiated Carbamates: alpha-Arylation of Benzylic Alcohols

J. Clayden, W. Farnaby, D. M. Grainger, U. Hennecke, M. Mancinelli, D. J. Tetlow, I. H. Hillier, M. A. Vincent, J. Am. Chem. Soc. 2009, 131, 3410-3411.

Synlett

α-Arylation of Cyclic Amines by Aryl Transfer in Lithiated Ureas

R. Bach, J. Clayden, U. Hennecke, Synlett 2009, 421-424.

Proc. Natl. Acad. Sci. U. S. A.

Recognition and Repair of UV Lesions in Loop Structures of Duplex DNA by DASH-Type Cryptochrome

R. Pokorny, T. Klar, U. Hennecke, T. Carell, A. Batschauer, L.-O. Essen, Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 21023-21027.

Synthesis

A General Route to 4-C-Substituted Pyrimidine Nucleosides

U. Hennecke, D. Kuch, T. Carell, Synthesis 2007, 929-935.

Science

CPD Damage Recognition by Transcribing RNA Polymerase II

F. Brückner, U. Hennecke, T. Carell, P. Cramer, Science 2007, 315, 859-862.

Journal-of-Biological-Chemistry.jpg

Characterization of a New Thermophilic Spore Photoproduct Lyase from Geobacillus stearothermophilus (SplG) with Defined Lesion Containing DNA Substrates

J. C. Pieck, U. Hennecke, A. J. Pierik, M. G. Friedel, T. Carell, J. Biol. Chem. 2006, 281, 36317-36326.

Chembiochem

Natural and Non-Natural Antenna Chromophores in the DNA Photolyase from Thermus Thermophilus

T. Klar, G. Kaiser, U. Hennecke, T. Carell, A. Batschauer, L.-O. Essen, ChemBioChem 2006, 7, 1798-1806.

Chem.: Eur. J

Investigation of the Pathways of Excess Electron Transfer in DNA with Flavin-Donor and Oxetane-Acceptor Modified DNA Hairpins

S. Breeger, M. von Meltzer, U. Hennecke, T. Carell, Chem. Eur. J. 2006, 12, 6469-6477.

Science

Crystal Structure of a Photolyase Bound to a CPD-Like DNA Lesion after in situ Repair

A. Mees, T. Klar, P. Gnau, U. Hennecke, A. P. M. Eker, T. Carell, L.-O. Essen, Science 2004, 306, 1789-1793.

Book cover Uli

Excess Electron Transfer in Defined Donor-Nucleobase and Donor-DNA-Acceptor Systems

C. Behrens, M. K. Cichon, F. Grolle, U. Hennecke, T. Carell, Top. Curr. Chem. 2004, 236, 187-204.

ACIE

Excess Electron Transport through DNA: a Single Electron Repairs More Than One UV-Induced Lesion

B. Giese, B. Carl, T. Carl, T. Carell, C. Behrens, U. Hennecke, O. Schiemann, E. Feresin, Angew. Chem. Int. Ed. 2004, 43, 1848-1851.

JACS

Excess Electron-Transfer-based Repair of a cis-syn Thymine Dimer in DNA is not Sequence Dependent

S. Breeger, U. Hennecke, T. Carell, J. Am Chem. Soc. 2004, 126, 1302-1303.

Design of Luminescent Polymers for LEDs

A. B. Holmes, A. D. Bond, J. E. Davies, C. Fischmeister, J. Frey, U. Hennecke, J. Li, Y. Ma, R. E. Martin, I. D. Rees, K. Robinson, T. Sano, F. Cacialli, S. F. Lim, R. H. Friend, Mater. Res. Soc. Symp. Proc. 2002, 708, 185-195.

New Family of Polyfluorene Copolymers for Light Emitting Devices

A. B. Holmes, I. Rees, T. Sano, C. Fischmeister, J. Frey, U. Hennecke, C.-S. Tuan, B. S. Chuah, Y. Ma, R. E. Martin, J. Li, N. Feeder, A. Bond, F. Cacialli, S. Lim, R. Friend, Proceedings of SPIE-The International Society for Optical Engineering 2002, 4464, 42-48.

Prof. Charlotte Martin

molecules

A New Family of Diverse Skin Peptides from the Microhylid Frog Genus Phrynomantis

Raaymakers, C.; Stijlemans, B.; Martin, C.; Zaman, S.; Ballet, S.; Martel, A.; Pasmans, F.; Roelants, K. Molecules 2020, 25(4), 912

Hollanders - ACS Catal 2020 - Cover

Zn-Catalyzed Nicotinate-Directed Transamidations in Peptide Synthesis

Hollanders, K.; Renders, E.; Gadais, C.; Masullo, D.; Van Raemdonck, L.; Wybon, C. C. D.; Martin, C.; Herrebout, W. A.; Maes, B. U. W.; Ballet, S. ACS Catal., 2020 DOI: 10.1021/acscatal.9b05074

Sci Adv

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.

Claff, T.; Yu, J.; Blais, V.; Patel, N.; Martin, C.; Wu, L.; Han, G. W.; Holleran, B. J.; Van der Poorten, O.; White, K. L.; Hanson, M. A.; Sarret, P.; Gendron, L.; Cherezov, V.; Katritch, V.; Ballet, S.; Liu, Z.-J.; Müller, C. E.; Stevens, R. C., Sci. Adv 2019, 5, eaax9115.

ACS Chem. Neurosci.

Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia.

Eiselt, E.; Gonzalez, S.; Martin, C.; Chartier, M.; Betti, C.; Longpré, J.-M.; Cavelier, F.; Tourwé, D.; Gendron, L.; Ballet, S.; Sarret, P., ACS Chem. Neurosci. 2019, 10, 4535-4544.

Gadais - graphical abstract TOC final.png

Trifluoromethylated Proline Surrogates as Part of “Pro–Pro” Turn-Inducing Templates.

Gadais, C.; Van holsbeeck, K.; Moors, S. L. C.; Buyst, D.; Fehér, K.; Van Hecke, K.; Tourwé, D.; Brigaud, T.; Martin, C.; De Proft, F.; Pytkowicz, J.; Martins, J. C.; Chaume, G.; Ballet, S., ChemBioChem 2019, 20, 2513-2518.

Bio Chem

Radiometal-labeled anti-VCAM-1 nanobodies as molecular tracers for atherosclerosis – impact of radiochemistry on pharmacokinetics.

Bala, G.; Crauwels, M.; Blykers, A.; Remory, I.; Marschall Andrea, L. J.; Dübel, S.; Dumas, L.; Broisat, A.; Martin, C.; Ballet, S.; Cosyns, B.; Caveliers, V.; Devoogdt, N.; Xavier, C.; Hernot, S., Biol. Chem., 2019; 400, 323.

Journal of peptide science

Trifluoromethylated proline surrogates as part of 'Pro-Pro' turn-inducing templates for the design of beta-hairpin mimetics.

Gadais, C.; Van Holsbeeck, K.; Moors, S.; Feher, K.; Pytkowicz, J.; Martins, J.; De Proft, F.; Tourwe, D.; Brigaud, T.; Martin, C.; Chaume, G.; Ballet, S., J. Pept. Sci. 2018, 24, S117-S117.

Journal of peptide science

A Bifunctional Biased Mu Opioid Agonist - Neuropeptide FF Receptor Antagonist as Analgesic with Improved Acute and Chronic Side Effects.

la Rochelle, A. D.; Guillemyn, K.; Dumitrascuta, M.; Gonzalez, S.; Martin, C.; Utard, V.; Quillet, R.; Schneider, S.; Daubeuf, F.; Willemse, T.; Mampuys, P.; Maes, B.; Frossard, N.; Bihel, F.; Spetea, M.; Simonin, F.; Ballet, S., J. Pept. Sci. 2018, 24, S156-S156.

Journal of peptide science

Injectable Peptide Hydrogels for Controlled Drug Release.

Mannes, M.; Martin, C.; Dumitrascuta, M.; Van Wanseele, Y.; Hernot, S.; Van Eeckhaut, A.; Madder, A.; Hoogenboom, R.; Spetea, M.; Ballet, S., J. Pept. Sci. 2018, 24, S159-S159.

Journal of peptide science

Design, synthesis and biological evaluation of stapled helical peptides targeting the myddosome.

Terriers, V.; Verhoeven, J.; Martin, C.; Hollanders, K.; Triballeau, N.; Mollat, P.; Van der Plas, S.; De Wilde, G.; Ballet, S., J. Pept. Sci. 2018, 24, S157-S157.

Journal of peptide science

Modulating peptide hydrogel strength through halogenation.

Vandeplassche, W.; Ballet, S.; Martin, C.; Hoogenboom, R.; Madder, A., J. Pept. Sci. 2018, 24, S109-S110.

Cover_JMedChem

Biodegradable Amphipathic Peptide Hydrogels as Extended-Release System for Opioid Peptides.

Martin, C.; Dumitrascuta, M.; Mannes, M.; Lantero, A.; Bucher, D.; Walker, K.; Van Wanseele, Y.; Oyen, E.; Hernot, S.; Van Eeckhaut, A.; Madder, A.; Hoogenboom, R.; Spetea, M.; Ballet, S., J. Med. Chem. 2018, 61, 9784-9789.

Pain

A bifunctional-biased mu-opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects.

la Rochelle, A. D.; Guillemyn, K.; Dumitrascuta, M.; Martin, C.; Utard, V.; Quillet, R.; Schneider, S.; Daubeuf, F.; Willemse, T.; Mampuys, P.; Maes, B. U. W.; Frossard, N.; Bihel, F.; Spetea, M.; Simonin, F.; Ballet, S., Pain 2018, 159, 1705-1718.

A de prins

Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.

De Prins, A.; Martin, C.; Van Wanseele, Y.; Tomboly, C.; Tourwe, D.; Caveliers, V.; Holst, B.; Van Eeckhaut, A.; Rosenkilde, M. M.; Smolders, I.; Ballet, S., ACS Med. Chem. Lett 2018, 9, 496-501.

Eur. J. Med. Chem

Development of potent and proteolytically stable human neuromedin U receptor agonists.

De Prins, A.; Martin, C.; Van Wanseele, Y.; Skov, L. J.; Tomboly, C.; Tourwe, D.; Caveliers, V.; Van Eeckhaut, A.; Holst, B.; Rosenkilde, M. M.; Smolders, I.; Ballet, S., Eur. J. Med. Chem. 2018, 144, 887-897.

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Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased beta(2) Adrenergic Receptor Ligands.

Martin, C.; Moors, S. L. C.; Danielsen, M.; Betti, C.; Fabris, C.; Pedersen, D. S.; Pardon, E.; Peyressatre, M.; Feher, K.; Martins, J. C.; Mathiesen, J. M.; Morris, M. C.; Devoogdt, N.; Caveliers, V.; De Proft, F.; Steyaert, J.; Ballet, S., Eur. Chem. J. 2017, 23, 9632-9640.

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The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis.

Rosado, L. A.; Wahni, K.; Degiacomi, G.; Pedre, B.; Young, D.; de la Rubia, A. G.; Boldrin, F.; Martens, E.; Marcos-Pascual, L.; Sancho-Vaello, E.; Albesa-Jove, D.; Provvedi, R.; Martin, C.; Makarov, V.; Versees, W.; Verniest, G.; Guerin, M. E.; Mateos, L. M.; Manganelli, R.; Messens, J., J. Biol. Chem. 2017, 292, 13097-13110.

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In Vivo Imaging of the Stability and Sustained Cargo Release of an Injectable Amphipathic Peptide-Based Hydrogel.

Oyen, E.; Martin, C.; Caveliers, V.; Madder, A.; Van Mele, B.; Hoogenboom, R.; Hemot, S.; Ballet, S., Biomacromolecules 2017, 18, 994-1001.

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Injectable peptide-based hydrogel formulations for the extended in vivo release of opioids.

Martin, C.; Oyen, E.; Van Wanseele, Y.; Ben Haddou, T.; Schmidhammer, H.; Andrade, J.; Waddington, L.; Van Eeckhaut, A.; Van Mele, B.; Gardiner, J.; Hoogenboom, R.; Madder, A.; Spetea, M.; Ballet, S., Materials Today Chemistry 2017, 3, 49-59.

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Controlled-release of opioids for improved pain management.

Martin, C.; De Baerdemaeker, A.; Poelaert, J.; Madder, A.; Hoogenboom, R.; Ballet, S., Mater. Today 2016, 19, 491-502.

Journal of peptide science

Development of Potent Neuromedin U Receptor Agonists.

De Prins, A.; Martin, C.; Caveliers, V.; Van Eeckhaut, A.; Holst, B.; Smolders, I.; Ballet, S., J. Pept. Sci. 2016, 22, S160-S160.

Journal of peptide science

Towards β-arrestin biased β2AR ligands: Rational Design of Nanobody Loop Mimetics.

Martin, C.; Betti, C.; Fabris, C.; Mathiesen, J. M.; Pardon, E.; Peyressatre, M.; Moors, S.; De Proft, F.; Feher, K.; Martins, J.; Morris, M. C.; Devoogdt, N.; Caveliers, V.; Steyaert, J.; Ballet, S., J. Pept. Sci. 2016, 22, S134-S134.

Journal of peptide science

Injectable Peptide Hydrogels for Controlled Drug Release.

Oyen, E.; Martin, C.; Hernot, S.; Gardiner, J.; Van Mele, B.; Madder, A.; Hoogenboom, R.; Spetea, M.; Ballet, S., J. Pept. Sci. 2016, 22, S84-S84

CM chem rev

Silicon-Containing Amino Acids: Synthetic Aspects, Conformational Studies, and Applications to Bioactive Peptides.

Remond, E.; Martin, C.; Martinez, J.; Cavelier, F., Chem. Rev. 2016, 116, 11654-11684.

Eur J Pharm

Biological evaluation and molecular docking studies of AA3052, a compound containing a μ-selective opioid peptide agonist DALDA and D-Phe-Phe-D-Phe-Leu-Leu-NH2, a substance P analogue

Kowalczyk, A.; Kleczkowska, P.; Rekawek, M.; Kulik, K.; Lesniak, A.; Erdei, A.; Borics, A.; Martin, C.; Pawlik, K.; Lipkowski, A. W.; Benyhe, S.; Makulska-Nowak, H.; Ballet, S.; Bujalska-Zadrozny, M., Eur. J. Pharm. Sci 2016, 93, 11-20.

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Injectable peptide hydrogels for controlled-release of opioids.

Martin, C.; Oyen, E.; Mangelschots, J.; Bibian, M.; Ben Haddou, T.; Andrade, J.; Gardiner, J.; Van Mele, B.; Madder, A.; Hoogenboom, R.; Spetea, M.; Ballet, S., MedChemComm 2016, 7, 542-549.

Chem.: Eur. J

Silaproline Helical Mimetics Selectively Form an All-trans PPII Helix.

Martin, C.; Legrand, B.; Lebrun, A.; Berthomieu, D.; Martinez, J.; Cavelier, F., Eur. Chem. J. 2014, 20, 14240-14244.

Journal of peptide science

Rational Design of Injectable Hexapeptide Hydrogelators for Controlled-Release Drug Delivery.

Bibian, M.; Mangelschots, J.; Martin, C.; Gardiner, J.; Waddington, L.; Acevedo, M. M. D.; Van Mele, B.; Madder, A.; Hoogenboom, R.; Ballet, S., J. Pept. Sci​​​​​​​. 2014, 20, S208-S208

Synthesis of homopolypeptides with PPII structure.

Martin, C.; Lebrun, A.; Martinez, J.; Cavelier, F., J. Polym. Sci. Part A: Polym. Chem. 2013, 51, 3103-3109.

Resolution of protected silaproline for a gram scale preparation.

Martin, C.; Vanthuyne, N.; Miramon, H.; Martinez, J.; Cavelier, F., Amino Acids 2012, 43, 649-655.

Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill.

Nun, P.; Martin, C.; Martinez, J.; Lamaty, F., Tetrahedron 2011, 67, 8187-8194.