![Tetrahedron Lett](/sites/default/files/styles/original_ratio_zero/public/2021-07/newseventsimage_1551378764138_mainnews2012_x1.jpg?itok=OMXVP0Tz)
In this Letter we explored the regioselective cyclization of 2-bromophenylalanine derivatives to access enantiopure dihydroquinolinones via an intramolecular regioselective Buchwald–Hartwig cyclization using Pd2(dba)3/XPhos as a catalytic system in the presence of BTPP as organic base. This procedure represents a promising strategy for the direct synthesis of bridged Phe-Xaa dipeptides.