![Org Lett](/sites/default/files/styles/original_ratio_zero/public/2021-07/orlef7_v018i016.jpg?itok=QHj0HtrD)
A simple and scalable one-pot biotransformation enables direct access to l-halotryptophans, including l-7-iodotryptophan, from the corresponding haloindoles. The biotransformation utilizes an easy to prepare bacterial cell lysate that may be stored as the lyophilizate for several months and utilized as a catalyst as and when required.