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The Influence of G-Quadruplex Structure on DNA-based Asymmetric Catalysis Using the G-Guadruplex-Bound Cationic Porphyrin TMPyP4·Cu

  • August 12, 2013

The DNA G-quadruplex-binding porphyrin TMPyP4·Cu was found to form efficient hybrid catalysts for DNA-based asymmetric catalysis when bound to DNA G-quadruplexes. Nucleobase substitution experiments using human telomere-derived G-quadruplex sequences suggest binding of the porphyrin on the 3′-face.


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