![OBC](/sites/default/files/styles/original_ratio_zero/public/2021-07/1045_obc_f2c-900.jpg?itok=rvZVfZal)
The DNA G-quadruplex-binding porphyrin TMPyP4·Cu was found to form efficient hybrid catalysts for DNA-based asymmetric catalysis when bound to DNA G-quadruplexes. Nucleobase substitution experiments using human telomere-derived G-quadruplex sequences suggest binding of the porphyrin on the 3′-face.