Our work towards Melanocortin 4 Receptor Ligand has made the cover
We are please to announce that our work on "Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure" made the cover of the journal of medicinal chemistry. For a full read, please check the publisher's page
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Identification and Characteristics of Fusion Peptides Derived From Enveloped Viruses
Lozada, C.; Barlow, T. M. A.; Gonzalez, S.; Lubin-Germain, N.; Ballet, S. Frontiers Chemistry (Chemical Biology) 2021, 9, 689006
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Neuromedin U induces an invasive phenotype in CRC cells expressing the NMUR2 receptor
Successful colorectal cancer (CRC) therapy often depends on the accurate identification of primary tumours with invasive potential. There is still a lack of identified pathological factors associated with disease recurrence that could help in making treatment decisions.
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Harnessing the anti-nociceptive potential of NK2 and NK3 ligands in the design of new multifunctional µ/δ-opioid agonist-neurokinin antagonist peptidomimetics.
Gadais, C.; Piekielna-Ciesielska, J.; De Neve, J.; Martin, C.; Janecka, A.; Ballet, S.
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Brønsted Acid-Catalysed Enantioselective Iodocycloetherification Enabled by Triphenylphosphine Selenide Cocatalysis
S. Guria, C. G. Daniliuc, U. Hennecke, Adv. Synth. Catal. 2021, 363, 3852-3858.
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Efficient Synthesis of Polysubstituted 1,5-Benzodiazepinone Dipeptide Mimetics via an Ugi-4CR-Ullmann Condensation Sequence
An efficient three-step synthesis towards 3-amino-1,4-benzodiazepin-2-one derivatives is presented. The versatile Ugi-4-component reaction (Ugi-4CR) and Boc deprotection is followed by a ligand-free Ullmann condensation.
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Efficient Synthesis of Polysubstituted 1,5-Benzodiazepinone Dipeptide Mimetics via an Ugi-4CR-Ullmann Condensation Sequence
An efficient three-step synthesis towards 3-amino-1,4-benzodiazepin-2-one derivatives is presented. The versatile Ugi-4-component reaction (Ugi-4CR) and Boc deprotection is followed by a ligand-free Ullmann condensation.
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Towards the understanding of halogenation in peptide hydrogels: a quantum chemical approach.
Bettens, T.; Lacanau, V.; Van Lommel, R.; De Maeseneer, T.; Vandeplassche, W.; Brancart, J.; Barlow, T.; Woller, T. M.; Van den Brande, N.; Moldenaers, P.; De Proft, F.; Madder, A.; Hoogenboom, R.; Martin, C.; Ballet, S.; Alonso Giner, M. Materials Advances, 2021 2(14), 4792-4803.
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Towards the understanding of halogenation in peptide hydrogels: a quantum chemical approach.
Bettens, T.; Lacanau, V.; Van Lommel, R.; De Maeseneer, T.; Vandeplassche, W.; Brancart, J.; Barlow, T.; Woller, T. M.; Van den Brande, N.; Moldenaers, P.; De Proft, F.; Madder, A.; Hoogenboom, R.; Martin, C.; Ballet, S.; Alonso Giner, M. Materials Advances, 2021 2(14), 4792-4803.
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Brønsted Acid-Catalyzed Enantioselective Iodocycloetherification Enabled by Triphenylphosphine Selenide Cocatalysis
Guria, S.; Daniliuc, C.G.; Hennecke, U.; Adv. Synth. Catal. 2021, 363, 3852-3858.
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3-Substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design
Hollanders, C.; Elsocht, M.; Van der Poorten, O.; Jida, M.; Renders, E.; Maes, B.U.W.; Ballet, S. Chem Comm, 2021, DOI: 10.1039/D1CC01701B...
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Antinociceptive Efficacy of the μ‐Opioid/Nociceptin Peptide‐Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking
Dumitrascuta, M.; Bermudez, M.; Trovato, O.; Neve, J.D.; Ballet, S.; Wolber, G.; Spetea, M., Molecules 2021, 26, 3267.
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