A dynamic picture of the halolactonization reaction through a combination of ab initio metadynamics and experimental investigations
R. Van Lommel, J. Bock, C.G. Daniliuc, U. Hennecke, F. De Proft, Chem. Sci. 2021, DOI: 10.1039/D1SC01014J.
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Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability
Tourwé, D.; Tsiailanis, A. D.; Parisis, N.; Hirmiz, B.; Del Borgo, M.; Aguilar, M.-I.; Van der Poorten, O.; Ballet, S.; Widdop, R. E.;Tzakos, A. G., Bioorg. Med. Chem. Lett, 2021, 43, 128086.
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Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors
De Neve, J.; Barlow, T. M.; Tourwé, D.; Bihel, F.; Simonin, F.; Ballet, S., RSC Med. Chem., 2021 DIO: 10.1039/D1MD00041A...
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New review on biased ligand for opiod receptors made the cover
We are pleased to announce that our review has been featured on the cover of RCS Medicinal Chemistry. For a full read, please visit the publisher's page
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Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking
Dumitrascuta, M.; Bermudez, M.; Trovato, O.; De Neve, J.; Ballet, S.; Wolber, G.; Spetea, M.
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Modification of the Pseudomonas aeruginosa toxin 2-heptyl-1-hydroxyquinolin-4(1H)-one and other secondary metabolites by methyltransferases from mycobacteria
P. Sartor, J. Bock, U. Hennecke, S. Thierbach, S. Fetzner, FEBS J. 2021, 288, 2360-2376.
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Enantioselective Dihalogenation of Alkenes
U. Hennecke, J. Bock, S. Guria, V. Wedek, Chem. Eur. J. 2021, 27, 4517-4530.
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Development of Generic G Protein Peptidomimetics Able to Stabilize Active State Gs Protein‐Coupled Receptors for Application in Drug Discovery
Mannes, M.; Martin, C.; Triest, S.; Pia Dimmito, M.; Mollica, A.; Laeremans, T.; Menet, C.J.; Ballet, S., Angew. Chem. Int. Ed. 2021. https://doi.org/10.1002/anie.202100180
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Constraining the Side Chain of C‑Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile
Trân, K.; Van Den Hauwe, R.; Sainsily, X.; Couvineau, P.; Côté, J.; Simard, L.; Echevarria, M.; Murza, A.; Serre, A.; Théroux, L.; Saibi, S.; Haroune, L.; Longpré, J-M.; Lesur, O.; Auger-Messier, M.; Spino, C.; Bouvier, M.; Sarret, P.; Ballet, S.; Marsault, E.; J. Med. Chem., ASAP...
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Structure–Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors
Elsocht, M.; Giron, P.; Maes, L.; Wim Versées. W.; Gutierrez, G.J.; De Grève, J.; Ballet S.; Int. J. Mol. Sci. 2021, 22(2), 635
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Enantioselective Dihalogenation of Alkenes
J. Bock, S. Guria, V. Wedek, U. Hennecke, Chem. Eur. J. 2021, 27, 4517-4530.
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Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure
Martin, C.; Gimenez, L. E.; Williams, S. Y.; Jing, Y.; Wu, Y.; Hollanders, C.; Van der Poorten, O.; Gonzalez, S.; Van holsbeeck, K.; Previti, S.; Lamouroux, A.; Zhao, S.; Tourwé, D.; Stevens R.C.; Cone R.D.; Ballet, S., J. Med. Chem. 2021, 64, 1, 357–369
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