Harnessing the anti-nociceptive potential of NK2 and NK3 ligands in the design of new multifunctional µ/δ-opioid agonist-neurokinin antagonist peptidomimetics.
Gadais, C.; Piekielna-Ciesielska, J.; De Neve, J.; Martin, C.; Janecka, A.; Ballet, S.
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Brønsted Acid-Catalysed Enantioselective Iodocycloetherification Enabled by Triphenylphosphine Selenide Cocatalysis
S. Guria, C. G. Daniliuc, U. Hennecke, Adv. Synth. Catal. 2021, 363, 3852-3858.
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Efficient Synthesis of Polysubstituted 1,5-Benzodiazepinone Dipeptide Mimetics via an Ugi-4CR-Ullmann Condensation Sequence
An efficient three-step synthesis towards 3-amino-1,4-benzodiazepin-2-one derivatives is presented. The versatile Ugi-4-component reaction (Ugi-4CR) and Boc deprotection is followed by a ligand-free Ullmann condensation.
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Efficient Synthesis of Polysubstituted 1,5-Benzodiazepinone Dipeptide Mimetics via an Ugi-4CR-Ullmann Condensation Sequence
An efficient three-step synthesis towards 3-amino-1,4-benzodiazepin-2-one derivatives is presented. The versatile Ugi-4-component reaction (Ugi-4CR) and Boc deprotection is followed by a ligand-free Ullmann condensation.
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Towards the understanding of halogenation in peptide hydrogels: a quantum chemical approach.
Bettens, T.; Lacanau, V.; Van Lommel, R.; De Maeseneer, T.; Vandeplassche, W.; Brancart, J.; Barlow, T.; Woller, T. M.; Van den Brande, N.; Moldenaers, P.; De Proft, F.; Madder, A.; Hoogenboom, R.; Martin, C.; Ballet, S.; Alonso Giner, M. Materials Advances, 2021 2(14), 4792-4803.
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Towards the understanding of halogenation in peptide hydrogels: a quantum chemical approach.
Bettens, T.; Lacanau, V.; Van Lommel, R.; De Maeseneer, T.; Vandeplassche, W.; Brancart, J.; Barlow, T.; Woller, T. M.; Van den Brande, N.; Moldenaers, P.; De Proft, F.; Madder, A.; Hoogenboom, R.; Martin, C.; Ballet, S.; Alonso Giner, M. Materials Advances, 2021 2(14), 4792-4803.
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Brønsted Acid-Catalyzed Enantioselective Iodocycloetherification Enabled by Triphenylphosphine Selenide Cocatalysis
Guria, S.; Daniliuc, C.G.; Hennecke, U.; Adv. Synth. Catal. 2021, 363, 3852-3858.
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3-Substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design
Hollanders, C.; Elsocht, M.; Van der Poorten, O.; Jida, M.; Renders, E.; Maes, B.U.W.; Ballet, S. Chem Comm, 2021, DOI: 10.1039/D1CC01701B...
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Antinociceptive Efficacy of the μ‐Opioid/Nociceptin Peptide‐Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking
Dumitrascuta, M.; Bermudez, M.; Trovato, O.; Neve, J.D.; Ballet, S.; Wolber, G.; Spetea, M., Molecules 2021, 26, 3267.
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A dynamic picture of the halolactonization reaction through a combination of ab initio metadynamics and experimental investigations
R. Van Lommel, J. Bock, C.G. Daniliuc, U. Hennecke, F. De Proft, Chem. Sci. 2021, DOI: 10.1039/D1SC01014J.
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Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability
Tourwé, D.; Tsiailanis, A. D.; Parisis, N.; Hirmiz, B.; Del Borgo, M.; Aguilar, M.-I.; Van der Poorten, O.; Ballet, S.; Widdop, R. E.;Tzakos, A. G., Bioorg. Med. Chem. Lett, 2021, 43, 128086.
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Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors
De Neve, J.; Barlow, T. M.; Tourwé, D.; Bihel, F.; Simonin, F.; Ballet, S., RSC Med. Chem., 2021 DIO: 10.1039/D1MD00041A...
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