Antimicrobial Activity of a Repurposed Harmine-Derived Compound on Carbapenem- Resistant Acinetobacter baumannii Clinical Isolates
Breine, A.; Van Gysel, M.; Elsocht, M.; Whiteway, C.; Philippe, C.; Quinet, T.; Valcek, A.; Wouters, J.; Ballet, S.; Van der Henst,. C.; Front. Cell. Infect. Microbiol. 2022, 11:789672.; doi: https://doi.org/10.1101/2021.06.30.45046
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Genome-based characterization of a plasmid-associated micrococcin P1 biosynthetic gene cluster and virulence factors in Mammaliicoccus sciuri IMDO-S72
Van der Veken, D.; Hollanders, C.; Verce, M.; Michiels, C.; Ballet, S.; Weckx, S.; Leroy, F. Applied and environmental microbiology, 2021, AEM-02088. DOI:10.1128/AEM.02088-21
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Downsizing antibodies: Towards complementarity-determining region (CDR)-based peptide mimetics
Monoclonal antibodies emerged as an important therapeutic drug class with remarkable specificity and binding affinity.
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Joint PhD position between ORGC and ALGC
We have an open PhD opportunity! Are you interested in synthetic organic chemistry and studying mechanisms both experimentally as well as computationally? A joint PhD positions between ORGC and ALGC research groups at the VUB is available wit...
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Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional mu/delta-Opioid Agonist–Neurokinin Antagonist Peptidomimetics
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use.
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Our work towards Melanocortin 4 Receptor Ligand has made the cover
We are please to announce that our work on "Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure" made the cover of the journal of medicinal chemistry. For a full read, please check the publisher's page
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Identification and Characteristics of Fusion Peptides Derived From Enveloped Viruses
Lozada, C.; Barlow, T. M. A.; Gonzalez, S.; Lubin-Germain, N.; Ballet, S. Frontiers Chemistry (Chemical Biology) 2021, 9, 689006
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Neuromedin U induces an invasive phenotype in CRC cells expressing the NMUR2 receptor
Successful colorectal cancer (CRC) therapy often depends on the accurate identification of primary tumours with invasive potential. There is still a lack of identified pathological factors associated with disease recurrence that could help in making treatment decisions.
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Harnessing the anti-nociceptive potential of NK2 and NK3 ligands in the design of new multifunctional µ/δ-opioid agonist-neurokinin antagonist peptidomimetics.
Gadais, C.; Piekielna-Ciesielska, J.; De Neve, J.; Martin, C.; Janecka, A.; Ballet, S.
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Brønsted Acid-Catalysed Enantioselective Iodocycloetherification Enabled by Triphenylphosphine Selenide Cocatalysis
S. Guria, C. G. Daniliuc, U. Hennecke, Adv. Synth. Catal. 2021, 363, 3852-3858.
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Efficient Synthesis of Polysubstituted 1,5-Benzodiazepinone Dipeptide Mimetics via an Ugi-4CR-Ullmann Condensation Sequence
An efficient three-step synthesis towards 3-amino-1,4-benzodiazepin-2-one derivatives is presented. The versatile Ugi-4-component reaction (Ugi-4CR) and Boc deprotection is followed by a ligand-free Ullmann condensation.
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Efficient Synthesis of Polysubstituted 1,5-Benzodiazepinone Dipeptide Mimetics via an Ugi-4CR-Ullmann Condensation Sequence
An efficient three-step synthesis towards 3-amino-1,4-benzodiazepin-2-one derivatives is presented. The versatile Ugi-4-component reaction (Ugi-4CR) and Boc deprotection is followed by a ligand-free Ullmann condensation.
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