Congratulations, Dr. Lozada
On Friday 23rd June, Camille Lozada – a joint PhD student of CY Cergy Paris University and the Vrije Universiteit Brussel – was given the opportunity to defend her PhD thesis entitled “ Alteration of the membranotropic properties of cell-penetrating and fusion peptides by means of conformatio...
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Prof. Ballet laureate of the Evotec Prize for Excellence in Molecular Design
On 19th June 2023, it was announced that Prof. Ballet had been awarded the Evotec Prize for Excellence in Molecular Design, awarded under the auspices of the French Medchem Society (Société de Chimie Thérapeutique, SCT). The prize was awarded for Prof.
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Workshop: Biomaterials
On the 24th of May, ORGC hosted the workshop “Biomaterials” of the FWO Scientific Research Network (FWO WOG) “Supramolecular Chemistry and Materials”. This workshop was organised by UGent, KU Leuven and UHasselt – alongside the VUB – and was attended by 45 participants.
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Determination of structural features that underpin the pannexin1 channel inhibitory activity of the peptide 10Panx1
Caufriez, A.; Lamouroux, A.; Martin, C.; Iaculli, D.; Ergüç, EI.; Gozalbes, R.; Mayan, M.D.; Kwak, B.R.; Tabernilla, A.; Vinken, M.; Ballet, S., Bioorg. Chem. 2023 DOI: 10.1016/j.bioorg.2023.106612
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Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS
Van holsbeeck, K., Fischer, B., Gonzalez, S., Gadais, C., Versées, W., Martins, J. C., Martin, C., Wohlkönig, A., Steyaert, J., Ballet, S., Angew. Chem. Int. Ed. 2023, e202219095; Angew. Chem. 2023, e202219095.
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Nature-Inspired Dual Purpose Strategy toward Cell-Adhesive PCL Networks: C(-linker-)RGD Incorporation via Thiol-ene Crosslinking
Thijssen, Q., Parmentier, L., Van Holsbeeck, K., Ballet, S. and Van Vlierberghe, S. Biomacromolecules 2023, 24(4), 1638-1647.
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Fast Self-Assembly Dynamics of a β-Sheet Peptide Soft Material
J. Bertouille, S. Kasas, C. Martin, U. Hennecke, S. Ballet, R. Willaert, R. G., Small, 2023, 2206795.
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Signaling Modulation via Minimal C‑Terminal Modifications of Apelin-13
Théroux, L.; Van Den Hauwe, R.; Trân, K.; Fournier, J.; Desgagné, M.; Meneboo, N.; Lavallée, A.; Fröhlich, U.; Côté, J.; Hollanders, C.; Longpré, J-M.; Murza, A.; Marsault, E.; Philippe Sarret, P.; Boudreault, P-L.; Ballet, S., ACS Pharmacol. Transl. Sci. 2023, DOI 10.1021/acsptsci.2c00219
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Second generation Spautin-1 analogues targeting EGFR-mutant non-small cell lung cancer cells
Elsocht, M., Giron, P., De Grève, J., Ballet, S. Bioorg. Med. Chem Lett. 2023, 79, 129066.
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Propargylamine Amino Acids as Constrained Nε‑Substituted Lysine Mimetics
Herein, alkylated propargylamines are reported as constrained lysine mimetics and constructed in a single step using a copper(I)-catalyzed A3-coupling reaction.
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Opening the amino acid toolbox for peptide-based NTS2-selective ligands as promising lead compounds for pain management
Chronic pain is one of the most critical health issues worldwide. Despite considerable efforts to find therapeutic alternatives, opioid drugs remain the gold standard for pain management.
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Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain management. Current pharmacotherapy offers unsatisfactory solutions due to serious side effects related to the chronic use of opioid drugs.
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