Nature-Inspired Dual Purpose Strategy toward Cell-Adhesive PCL Networks: C(-linker-)RGD Incorporation via Thiol-ene Crosslinking
Thijssen, Q., Parmentier, L., Van Holsbeeck, K., Ballet, S. and Van Vlierberghe, S. Biomacromolecules 2023, 24(4), 1638-1647.
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Fast Self-Assembly Dynamics of a β-Sheet Peptide Soft Material
J. Bertouille, S. Kasas, C. Martin, U. Hennecke, S. Ballet, R. Willaert, R. G., Small, 2023, 2206795.
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Signaling Modulation via Minimal C‑Terminal Modifications of Apelin-13
Théroux, L.; Van Den Hauwe, R.; Trân, K.; Fournier, J.; Desgagné, M.; Meneboo, N.; Lavallée, A.; Fröhlich, U.; Côté, J.; Hollanders, C.; Longpré, J-M.; Murza, A.; Marsault, E.; Philippe Sarret, P.; Boudreault, P-L.; Ballet, S., ACS Pharmacol. Transl. Sci. 2023, DOI 10.1021/acsptsci.2c00219
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Second generation Spautin-1 analogues targeting EGFR-mutant non-small cell lung cancer cells
Elsocht, M., Giron, P., De Grève, J., Ballet, S. Bioorg. Med. Chem Lett. 2023, 79, 129066.
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Propargylamine Amino Acids as Constrained Nε‑Substituted Lysine Mimetics
Herein, alkylated propargylamines are reported as constrained lysine mimetics and constructed in a single step using a copper(I)-catalyzed A3-coupling reaction.
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Opening the amino acid toolbox for peptide-based NTS2-selective ligands as promising lead compounds for pain management
Chronic pain is one of the most critical health issues worldwide. Despite considerable efforts to find therapeutic alternatives, opioid drugs remain the gold standard for pain management.
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Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain management. Current pharmacotherapy offers unsatisfactory solutions due to serious side effects related to the chronic use of opioid drugs.
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Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain management. Current pharmacotherapy offers unsatisfactory solutions due to serious side effects related to the chronic use of opioid drugs.
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Impact of doubling peptide length on in vivo hydrogel stability and sustained drug release
Heremans, J.; Chevillard, L.; Mannes, M.; Mangialetto, J.; Leroy, K; White, J.F.; Lamouroux, A.; Vinken, M.; Gardiner, J.; Van Mele, B.; Van den Brande, N.; Hoogenboom, R.; Madder, A.; Caveliers, V.; Mégarbane ,B.; Hernot, S.; Ballet, S.; Martin, C., Journal of Controlled Release, 2022,350, 514-524
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Impact of doubling peptide length on in vivo hydrogel stability and sustained drug release
Heremans, J., Chevillard, L., Mannes, M., Mangialetto, J., Leroy, K., White, J.F., Lamouroux, A., Vinken, M., Gardiner, J., Van Mele, B. and Van den Brande, N., Hoogenboom, R., Madder, A., Caveliers, V., Mégarbane, B., Hernot, S., Ballet, S., Martin, C., J. Controlled Release, 2022, 350, 514-524.
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ORGC brings home the prices at EPS
What a fantastic result for ORGC! 🎊 At this year's European Peptide Symposium, which was held last week in Sitges, two of our talented researchers were recognised: our very own Julie Heremans won the 2nd Prize 🏅 in the Dr. Bert and Dr.
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