Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects after Subcutaneous Administration in Mice
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain management. Current pharmacotherapy offers unsatisfactory solutions due to serious side effects related to the chronic use of opioid drugs.
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Impact of doubling peptide length on in vivo hydrogel stability and sustained drug release
Heremans, J.; Chevillard, L.; Mannes, M.; Mangialetto, J.; Leroy, K; White, J.F.; Lamouroux, A.; Vinken, M.; Gardiner, J.; Van Mele, B.; Van den Brande, N.; Hoogenboom, R.; Madder, A.; Caveliers, V.; Mégarbane ,B.; Hernot, S.; Ballet, S.; Martin, C., Journal of Controlled Release, 2022,350, 514-524
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Impact of doubling peptide length on in vivo hydrogel stability and sustained drug release
Heremans, J., Chevillard, L., Mannes, M., Mangialetto, J., Leroy, K., White, J.F., Lamouroux, A., Vinken, M., Gardiner, J., Van Mele, B. and Van den Brande, N., Hoogenboom, R., Madder, A., Caveliers, V., Mégarbane, B., Hernot, S., Ballet, S., Martin, C., J. Controlled Release, 2022, 350, 514-524.
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ORGC brings home the prices at EPS
What a fantastic result for ORGC! 🎊 At this year's European Peptide Symposium, which was held last week in Sitges, two of our talented researchers were recognised: our very own Julie Heremans won the 2nd Prize 🏅 in the Dr. Bert and Dr.
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A Quantum Chemical Deep-Dive into the pi-pi Interactions of 3-Methylindole and Its Halogenated Derivatives—Towards an Improved Ligand Design and Tryptophan Stacking
Van Lommel, R.; Bettens, T.; Barlow, T.M.A.; Bertouille, J.; Ballet, S.; De Proft, F. Pharmaceuticals 2022, 15, 935. https://doi.org/10.3390/ph15080935
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Dr. Mannes wins best oral communication at GFPP-BPGM
A huge congratulations to our talented researcher Dr. Mannes, who, last week, won best oral communication for her presentation on her PhD research at this year's French-Belgian Joint Meeting of peptide and protein research groups in Port Leucate.
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Azetidomonamide and diazetidomonapyridone metabolites control biofilm formation and pigment synthesis in Pseudomonas aeruginosa
S. Ernst, A. Volkov, M. Stark, L. Hölscher, K. Steinert, S. Fetzner, U. Hennecke, S. L. Drees, J. Am. Chem. Soc. 2022, 144, 7676-7685.
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Our review on peptides as allosteric protein modulators made the cover!
We are trilled to announce that our review that wanders beyond small molecules and focusses on peptides as allosteric protein modulators is featured on the cover of Trends in Pharmacological Sciences. For a full read, click here.
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Azetidomonamide and Diazetidomonapyridone Metabolites Control Biofilm Formation and Pigment Synthesis in Pseudomonas aeruginosa
Ernst, S.; Volkov, A.N.; Stark, M.; Hölscher, L.; Steinert, K.; Fetzner, S.; Hennecke, U.; Drees, S.L.; J. Am. Chem. Soc. 2022, 144, 7676-7685
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Our work focussing on convertable isocyanides made the cover
We are proud to announch that our work on "3-substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design" has been picked up on the cover of ChemComm. For the full read, you can check the publisher's page
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Wandering beyond small molecules: peptides as allosteric protein modulators
Mannes, M.; Martin, C.; Menet, C.; Ballet, S. Trends Pharmacol. Sci. 2021, , 43(5), 406-423
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