A Quantum Chemical Deep-Dive into the pi-pi Interactions of 3-Methylindole and Its Halogenated Derivatives—Towards an Improved Ligand Design and Tryptophan Stacking
Van Lommel, R.; Bettens, T.; Barlow, T.M.A.; Bertouille, J.; Ballet, S.; De Proft, F. Pharmaceuticals 2022, 15, 935. https://doi.org/10.3390/ph15080935
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Dr. Mannes wins best oral communication at GFPP-BPGM
A huge congratulations to our talented researcher Dr. Mannes, who, last week, won best oral communication for her presentation on her PhD research at this year's French-Belgian Joint Meeting of peptide and protein research groups in Port Leucate.
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Azetidomonamide and diazetidomonapyridone metabolites control biofilm formation and pigment synthesis in Pseudomonas aeruginosa
S. Ernst, A. Volkov, M. Stark, L. Hölscher, K. Steinert, S. Fetzner, U. Hennecke, S. L. Drees, J. Am. Chem. Soc. 2022, 144, 7676-7685.
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Our review on peptides as allosteric protein modulators made the cover!
We are trilled to announce that our review that wanders beyond small molecules and focusses on peptides as allosteric protein modulators is featured on the cover of Trends in Pharmacological Sciences. For a full read, click here.
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Azetidomonamide and Diazetidomonapyridone Metabolites Control Biofilm Formation and Pigment Synthesis in Pseudomonas aeruginosa
Ernst, S.; Volkov, A.N.; Stark, M.; Hölscher, L.; Steinert, K.; Fetzner, S.; Hennecke, U.; Drees, S.L.; J. Am. Chem. Soc. 2022, 144, 7676-7685
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Our work focussing on convertable isocyanides made the cover
We are proud to announch that our work on "3-substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design" has been picked up on the cover of ChemComm. For the full read, you can check the publisher's page
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Wandering beyond small molecules: peptides as allosteric protein modulators
Mannes, M.; Martin, C.; Menet, C.; Ballet, S. Trends Pharmacol. Sci. 2021, , 43(5), 406-423
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Antimicrobial Activity of a Repurposed Harmine-Derived Compound on Carbapenem- Resistant Acinetobacter baumannii Clinical Isolates
Breine, A.; Van Gysel, M.; Elsocht, M.; Whiteway, C.; Philippe, C.; Quinet, T.; Valcek, A.; Wouters, J.; Ballet, S.; Van der Henst,. C.; Front. Cell. Infect. Microbiol. 2022, 11:789672.; doi: https://doi.org/10.1101/2021.06.30.45046
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Genome-based characterization of a plasmid-associated micrococcin P1 biosynthetic gene cluster and virulence factors in Mammaliicoccus sciuri IMDO-S72
Van der Veken, D.; Hollanders, C.; Verce, M.; Michiels, C.; Ballet, S.; Weckx, S.; Leroy, F. Applied and environmental microbiology, 2021, AEM-02088. DOI:10.1128/AEM.02088-21
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Downsizing antibodies: Towards complementarity-determining region (CDR)-based peptide mimetics
Monoclonal antibodies emerged as an important therapeutic drug class with remarkable specificity and binding affinity.
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Joint PhD position between ORGC and ALGC
We have an open PhD opportunity! Are you interested in synthetic organic chemistry and studying mechanisms both experimentally as well as computationally? A joint PhD positions between ORGC and ALGC research groups at the VUB is available wit...
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Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional mu/delta-Opioid Agonist–Neurokinin Antagonist Peptidomimetics
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use.
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