Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design
Luis E. Gimenez, C. Martin, J. Yu, C. Hollanders, Ciria C. Hernandez, Y. Wu, D. Yao,G. Won Han, Naima S. Dahir, L. Wu, O. Van der Poorten, A. Lamouroux, M. Mannes, S. Zhao, D. Tourwé, RC. Stevens, RD. Cone, S. Ballet, J. Med. Chem. 2024, 67, 4, 2690–2711 doi.org/10.1021/acs.jmedchem.3c01822
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Sustained release of a human PD-L1 single-domain antibody using peptide-based hydrogels
Heremans, J., Maximilian Awad, R., Bridoux, J., Ertveldt, T., Caveliers V., Madder A., Hoogenboom R., Devoogdt N., Ballet S., Hernot S., Breckpot K., Martin C., Eur J Pharm Biopharm 2024 Mar:196:114183. doi.org/10.1016/j.ejpb.2024.114183 .
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Vacature technisch expert
Technisch expert - Organische chemie, vakgroepen Chemie en Bio-ingenieurswetenschappen Categorie: Management & Professionals 1 - Werken bij de VUB Ben jij onze Technisch Expert Ingenieur die graag uitkijkt naar e...
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ORGC is Recipient of Innoviris Proof-of-Concept Funding to screen a small-molecule library for application in pancreatic cancer
At the start of November, ORGC became the recipient of Innoviris (Brussels Capital Region) proof-of-concept funding to undertake a high-throughput screening of a commercial small molecule library to discovery lead compounds for further medicinal chemistry work.
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ORGC Receives FWO Project funding to develop G protein Peptidomimetics
On December 13th, the FWO announced the results of this year’s applications for Junior and Senior Research Projects.
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ORGC Receives FWO Project funding to develop inhibitors of a viral protein-protein interaction
On December 13th, the FWO announced the results of this year’s applications for WEAVE Research Projects with various partner countries and regions. ORGC – alongside our partner Dr.
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Another award for ORGC!
At the 15th Australian Peptide Conference 🇦🇺 and 13th International Peptide Symposium! 🌏 in Brisbane, our phenomenal student Debora was honoured with first place in the 13th IPS Poster Award supported by Mimotopes, recognising her outstanding PhD research.
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Structure-Based Design and Synthesis of Stapled 10Panx1 Analogues for Use in Cardiovascular Inflammatory Diseases
Lamouroux, A.; Tournier, M.; Iaculli, D.; Caufriez, A.; Rusiecka, O.M.; Martin, C.; Bes, V.; Carpio, L.E.; Girardin, Y.; Loris, R.; Tabernilla, A.; Molica, F.; Gozalbes, R.; Mayán, M.D.; Vinken, M.; Kwak, B.R.; Ballet, S.; J. Med. Chem. 2023, 66, 18, 13086–13102
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Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions
Braet, H.; Fransen, P.-P.; Chen, Y.; Van Herck, S.; Mariën, R.; Vanhoorne, V.; Ceelen, W.; Madder, A.; Ballet, S.; Hoogenboom, R.; De Geest, B.; Hoorens, A.; Dankers, P.Y.W.; De Smedt, S.C.; Remaut, K.; J. Control Release, 2023, 362, 138-150
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Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction
Maseko, S.B.; Brammerloo, Y.; Van Molle, I.; Sogues, A.; Martin, C.; Gorgulla, C.; Plant, E.; Olivet, J.; Blavier, J.; Ntombela, T.; Delvigne, F.; Arthanari, H.; El Hajj, H.; Bazarbachi, A.; Van Lint, C.; Salehi-Ashtiani, K.; Remaut, H.; Ballet, S.; Volkov, A.N.; Twizere, J-C.; Antiviral Research, 2
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Bypassing the Need for Cell Permeabilization: Nanobody CDR3 Peptide Improves Binding on Living Bacteria
Breine, A.; Van holsbeeck, K.; Martin, C.; Gonzalez, S.; Mannes, M.; Pardon, E.; Steyaert, J.; Remaut, H.; Ballet, S.; Van der Henst, C.; Bioconjugate Chem. 2023, 34, 7, 1234-1243
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Introduction of constrained Trp analogs in RW9 modulates structure and partition in membrane models
Lozada, C.; Simon Gonzalez, S.; Agniel, R.; Hindie, M.; Manciocchi, L.; Mazzanti, L.; Ha-Duong, T.; Federica Santoro, F.; Carotenuto, A.; Ballet, S.; Lubin-Germain, N.; Bioorganic chemistry, 2023, 139, 106731
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